Effect of Motilin on Gastric Emptying in Patients With Diabetic Gastroparesis

  1. Meinhard Classen, MD
  1. Department of Internal Medicine II and the Department of Nuclear Medicine, Technical University of Munich Munich, Germany
  1. Address correspondence and reprint requests to Dr. V. Schusdziarra, Department of Internal Medicine II, Technical University of Munich, Ismaninger Strasse 22, D-8000 Munchen 80, Germany.


Oobjectives Because disturbances of gastric emptying are a serious complication in insulin-dependent diabetic subjects with regard to the maintenance of good metabolic control, we wanted to assess the effectiveness of motilin as a potential treatment for gastric emptying disturbances.

Research Design and Methods The intestinal hormone motilin has been shown to accelerate gastric emptying in healthy subjects. Therefore, we examined the effect of intravenous motilin on gastric emptying of a 99mTc colloid-labeled semisolid test meal in 9 insulin-dependent diabetic patients with diabetic gastroparesis. All patients had a significantly delayed gastric emptying rate compared with a group of 11 healthy control subjects.

Results During the infusion of motilin, gastric emptying was accelerated, and it was no longer significantly different from control values.

Conclusions These data demonstrate that motilin and related compounds such as erythromycin derivatives could be useful for the treatment of disturbed gastric emptying in diabetic subjects.

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