Effects of Benfluorex on Insulin Resistance and Lipid Metabolism in Obese Type II Diabetic Patients
- Rutgert Bianchi, MD,
- Vivian Bongers,
- Bert Bravenboer, MD and
- D Willem Erkelens, MD
- Address correspondence and reprint request to Rutgert Bianchi, Md, Department of Internal Medicine, University Hospital Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Abstract
OBJECTIVE To evaluate the change in lipids and insulin sensitivity in 10 obese type II diabetic patients after treatment with benfluorex or placebo for 2 wk.
RESEARCH DESIGN AND METHODS The study had a double-blind, cross-over design. Insulin sensitivity was measured with the euglycemic hyperinsulinemic glucose clamp technique at two different insulin infusion rates: 0.05 (clamp 1) and 0.10 U.kg−1 · h−1 (clamp 2).
RESULTS Subanalysis of the glucose infusion rate under steady-state conditions in the last 30 min of clamp 2 yielded a glucose infusion rate of 5.36 and 3.87 mmol.kg−1.min−1 after benfluorex and placebo, respectively (P = 0.018).
CONCLUSIONS Benfluorex increases insulin sensitivity in obese type II diabetic patients.
- Received April 14, 1992.
- Revision received December 11, 1992.
- Accepted December 11, 1992.
- Copyright © 1993 by the American Diabetes Association
