Urinary chiro-Inositol Excretion is an Index Marker of Insulin Sensitivity in Japanese Type II Diabetes
- Susumu Suzuki, MD,
- Hiromasa Kawasaki, MD,
- Yoshinori Satoh, MD,
- Masataka Ohtomo, MD,
- Masashi Hirai, MD,
- Aki Hirai, MD,
- Satoshi Hirai, MD,
- Masatoshi Onoda, MD,
- Masahiro Matsumoto, MD,
- Yoshinori Hinokio, MD,
- Hiroaki Akai, MD,
- James Craig, MD,
- Joseph Larner, MD, PHD and
- Takayoshi Toyota, MD
- Third Department of Internal Medicine, Tohoku University School of Medicine Sendai, Japan; and the Department of Pharmacology, University of Virginia School of Medicine Charlottesville, Virginia
- Address correspondence and reprint requests to Susumu Suzuki, MD, Third Department of Internal Medicine, Tohoku University School of Medicine, 1–1 Seiryou-machi, Aoba-ku, 980–77 Sendai, Japan.
Abstract
OBJECTIVE To determine the relationship between urinary chiro-inositol excretion and insulin sensitivity in Japanese type II diabetic patients.
RESEARCH DESIGN AND METHODS Eighteen subjects were age-matched, nonobese, type II diabetic patients. Eight subjects had impaired glucose tolerance (IGT), and 10 had normal glucose tolerance (NGT). We quantified urinary chiro-inositol excretion using gas chromatography-mass spectrometry and the insulin sensitivity index (SI), and glucose effectiveness (SG) using Bergman's modified minimal model method.
RESULTS The urinary excretion of chiro-inositol was much lower in the diabetic patients (32.3 ± 16.0 μmol/day, means ± SD) than in the NGT subjects (96.0 ± 17.6; P < 0.0001) and IGT subjects (58.9 ± 11.6; P < 0.0001). SI was much lower in the diabetic patients (3.81 ± 1.49) than in the NGT subjects 6.30 ± 1.59, P < 0.0005). SG was much lower in the diabetic patients (2.14 ± 0.56) than in the NGT subjects (3.07 ± 0.38, P < 0.0001). There was a significant correlation between urinary chiro-inositol excretion and SI (r = 0.766), as well as a significant correlation between urinary chiro-inositol excretion and SG (r = 0.747).
CONCLUSIONS There is a direct relationship of urinary chiro-inositol excretion to insulin sensitivity and SG in humans. Urinary chiro-inositol excretion might be useful as a metabolic index of insulin sensitivity in type II diabetes.
- Received April 8, 1994.
- Revision received June 30, 1994.
- Accepted June 30, 1994.
- Copyright © 1994 by the American Diabetes Association
