Remission of Proteinuria Following Correction of Hyperlipidemia in NIDDM Patients With Nondiabetic Glomerulopathy
- Daniéle Dubois, MD,
- Philippe Chanson, MD,
- José Timsit, MD,
- Dominique Chauveau, MD,
- Dominique Nochy, MD,
- Pierre-Jean Guillausseau, MD and
- Jean Lubetzki, MD
- Service de Médecine Interne, Hôpital Lariboisière, Hôpital Broussais Paris, France
- Service d'Immunologie Clinique, Hôpital Broussais Paris, France
- Service de Néphrologie, Hôpital Broussais Paris, France
- Hôpital Necker, and Service d'Anatomo-Pathologie, Hôpital Broussais Paris, France
- Address correspondence and reprint requests to Philippe Chanson, MD, Service d'Endocrinologie, Hôpital de Bicêtre, 78, rue du Général Leclerc, F94270 Le Kremlin Bicêtre, France.
Abstract
OBJECTIVE Animal studies suggest that hyperlipidemia may play a direct role in glomerular damage. In patients with non-insulin-dependent diabetes mellitus (NIDDM), dyslipidemia occurs early in the course of nephropathy and may be involved in the progression of renal disease.
CASES We report on two young NIDDM patients with marked hyperlipidemia and proteinu ria, in whom renal biopsy demonstrated nondiabetic glomerulopathy. In both cases, the decrease in blood lipid levels was associated with a major decrease in proteinuria. Episodes of hyperlipidemia were associated with a resumption of heavy protcinuria in one patient with serum triglyceride levels and proteinuria being closely correlated.
CONCLUSIONS These two cases suggest that hyperlipidemia has an important rolein the pathogenesis of glomerular disease.
- Received October 25, 1993.
- Accepted March 24, 1994.
- Copyright © 1994 by the American Diabetes Association
