Insulin Sensitivity and Lp(a) Concentrations in Normoglycemic Men
- Steven M Haffner, MD,
- Pauli Karhapaa, MD,
- David L Rainwater, PHD,
- Leena Mykkanen, MD,
- Gilbert Aldrete Jr, BA and
- Markku Laakso, MD
- Department of Medicine, Division of Clinical Epidemiology, Southwest Foundation for Biomedicai Research San Antonio, Texas
- University of Texas Health Science Center at San Antonio and the Department of Genetics, Southwest Foundation for Biomedicai Research San Antonio, Texas
- Department of Medicine, University of Kuopio Kuopio, Finland
- Department of Medicine, Division of Medical Genetics, University of Washington Seattle, Washington
- Address correspondence and reprint requests to Steven M. Haffner, MD, University of Texas Health Science Center at San Antonio, Division of Clinical Epidemiology, Department of Medicine, 7703 Floyd Curl Dr., San Antonio, TX 78284–7873.
Abstract
OBJECTIVE Increased lipoprotein(a) [Lp(a)] concentrations have been recognized as a risk factor for coronary heart disease. Little data exists on the relationship of Lp(a) concentrations to insulin resistance.
RESEARCH DESIGN AND METHODS We examined insulin resistance (as determined by the euglycemic clamp) together with indirect calorimetry in relation to Lp(a) concentrations, apolipoprotein(a) [apo(a)] molecular weight, and apo(a) phe-notype in 87 normoglycemic men.
RESULTS Lp(a) concentrations were significantly related to total (r = 0.225) and nonoxidative (r = 0.256) whole-body glucose disposal. These results suggest a positive but weak association between insulin sensitivity (restricted to the nonoxidative whole-body glucose disposal) and Lp(a) concentrations. However, after adjustment for apo(a) molecular weight [which accounts for some of the genetic influences on Lp(a) levels], total and nonoxidative body glucose disposal were not significantly related to Lp(a) concentrations.
CONCLUSIONS Normoglycemic insulin-resistant subjects do not have elevated Lp(a) concentrations.
- Received April 26, 1994.
- Revision received September 22, 1994.
- Accepted September 22, 1994.
- Copyright © 1995 by the American Diabetes Association
