Hypertriglyceridemia Enhances Monocyte Binding to Endothelial Cells in NIDDM
- Nicoline Hoogerbrugge, MD,
- Anton Verkerk,
- Marloes L Jacobs, MD,
- Pieter TE Postema, MD and
- Johan F Jongkind, PHD
- Department of Internal Medicine III, Erasmus University Rotterdam, The Netherlands
- University Hospital Rotterdam “Dijkzigt”, and the Department of Cell Biology and Genetics, Erasmus University Rotterdam, The Netherlands
- Address correspondence and reprint requests to Nicoline Hoogerbrugge, MD, Department of Internal Medicine 111, University Hospital “Dijkzigt”, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. E-mail: hoogerbrugge{at}inw3.azr.nl
Abstract
OBJECTIVE The mechanisms by which diabetes leads to rapidly progressive atherosclerosis are not fully understood. Adherence of monocytes to the arterial wall is an early event in the development of atherosclerotic lesions.
RESEARCH DESIGN AND METHODS The binding of freshly isolated monocytes from patients with NIDDM, IDDM, and healthy control subjects to a monolayer of endothelial cells obtained from human umbilical vein was investigated.
RESULTS Endothelial adherence of monocytes from normolipidemic patients with IDDM (15.8 ± 4.5%) or NIDDM (16.9 ± 4.6%) was comparable to that of monocytes from a control population (15.3 ± 3.5%). In patients with NIDDM with a serum triglyceride concentration > 2.5 mmol/l, the percentage of cells that adhere to endothelial cells in vitro was significantly increased (23.3 ± 3.1%). Glycemic control did not correlate with monocyte adherence. The presence of symptomatic atherosclerotic disease, age, or sex was not associated with a change in monocyte binding in vitro.
CONCLUSIONS The results suggest that in NIDDM hypertriglyceridemia should be treated to reduce the high risk for atherosclerosis.
- Received February 8, 1996.
- Revision received May 30, 1996.
- Accepted May 30, 1996.
- Copyright © 1996 by the American Diabetes Association
