Reduced Decrease of Peripheral Vascular Resistance During Exercise in Young Type I Diabetic Patients
- Dirk Matthys, MD,
- Margaretha Craen, MD,
- Daniel De Wolf, MD,
- Johan Vande Walle, MD and
- Henri Verhaaren, MD, PHD
- Address correspondence and reprint requests to Dirk Matthys, MD, Kliniek voor Kinderziekten “C. Hooft,” Univcrsitair Ziekenhuis Gent, De Pintelaan 185, 9000 Gent, Belgium. E-mail address: dirk.matthys{at}rug.ac.be
Abstract
OBJECTIVE In normal subjects, peripheral vascular resistance decreases during dynamic exercise. We studied blood pressure and peripheral vascular resistance responses to dynamic exercise in young normotensive type I diabetic patients.
RESEARCH DESIGN AND METHODS Thirty adolescent diabetic patients (9–19 years of age) underwent a maximal exercise test on a cycle ergometer. In a subset of 14 patients, cardiac output was measured by a CO2 rebreathing method and peripheral vascular resistance was calculated. Twenty-four normal individuals, age and sex matched, served as control subjects.
RESULTS Diastolic blood pressure was significantly higher in diabetic patients at intermediate workload (77 ± 2 vs. 71 ± 1 mmHg) and peak exercise (86 ± 2 vs. 73 ± 2 mmHg). Peripheral vascular resistance was significantly higher in diabetic patients at intermediate workload (17.0 ± 1.1 vs. 12.6 ± 0.5 mmHg·l−1 · min−1 · m−2) and peak exercise (16.3 ± 1.3 vs. 11.4 ± 0.5 mmHg ·l−1 · min−1 · m−2). There were no significant correlations with the patient's age, diabetes duration, or diabetes control.
CONCLUSIONS We observed the decrease of vasodilator response during dynamic exercise in normotensive young type I diabetic patients.
- Received March 4, 1996.
- Revision received June 13, 1996.
- Accepted June 13, 1996.
- Copyright © 1996 by the American Diabetes Association
