Accuracy of home blood glucose meters during hypoglycemia
- Z Trajanoski, PHD,
- GA Brunner, MD,
- RJ Gfrerer, MSC,
- P Wach, PHD and
- TR Pieber, MD
- Department of Biophysics, Institute of Biomedical Engineering, Graz University of Technology Graz, Austria
- Ludwig Boltzmann Institut fur Technische Lebenshilfen, Diabetes and Metabolism, Karl Franzens University Graz, Austria
- Department of Internal Medicine, Diabetes and Metabolism, Karl Franzens University Graz, Austria
- Address correspondence and reprint requests to Zlatko Trajanoski, PhD, Department of Biophysics, Institute of Biomedical Engineering, Graz University of Technology, Inffeldgasse 18, 8010 Graz, Austria. E-mail: trajanoski{at}ibmt.tu-graz.ac.at.
Abstract
OBJECTIVE To evaluate the accuracy of home blood glucose meters during hypoglycemia.
METHODS Six blood glucose meters—One Touch II (LifeScan, Milpitas, CA), Companion II (Medisense, Cambridge, U.K.), Reflolux (Boehringer Mannheim, Mannheim, Germany), Accutrend (Boehringer Mannheim), Elite (Bayer, Munich, Germany), and HemoCue (HemoCue, Ängelholm, Sweden)—were compared with a reference method (Beckman Glucose Analyzer 2). Glucose concentrations from arterialized venous blood samples were measured using all glucose meters (whole blood) and the reference method (plasma) during hypoglycemic-hyperinsulinemic clamps in 15 subjects.
RESULTS In total, 663 blood glucose monitor readings and 119 reference values ranging from 2.28 to 3.89 mmol/l were analyzed. The correlation coefficients and the percentage of measurements within 20% and outside 40% of the reference values for each glucose meter were as follows: One Touch II: 0.91, 99.2% and 0%; Companion II: 0.81, 88.2% and 2.5%; Reflolux: 0.78, 85.0% and 0.9%; Accutrend: 0.88, 46.0% and 6.6%; Elite: 0.78, 75.6% and 4.2%; and HemoCue: 0.93, 96.6% and 0% (P < 0.001).
CONCLUSIONS There were substantial differences between the blood glucose meters during hypoglycemia, and none of the devices met the latest criteria recommended by the American Diabetes Association.
- Received November 28, 1995.
- Revision received August 5, 1996.
- Accepted August 5, 1996.
- Copyright © 1996 by the American Diabetes Association
