Relationship Between Weight Change in Young Adulthood and the Risk of NIDDM: The Sotetsu Study
- Yutaka Sakurai, MD,
- Koji Teruya, MD,
- Naoki Shimada, MD,
- Kazuo Wakabayashi, PHD,
- Takashi Umeda, MPHYED,
- Satoshi Honjo, MD,
- Isao Todoroki, MD,
- Hiroyuki Tanaka, MD,
- Takashi Muto, MD,
- Masaru Sakurai, MD and
- Kou Nakamura, MD
- Department of Public Health, Sagami Railway Co. Ltd. Yokohama, Japan
- National Defense Medical College Saitama Departments of Hygiene, Sagami Railway Co. Ltd. Yokohama, Japan
- Department of 2nd Surgery, School of Medicine, Kyorin University Tokyo Department of Preventive Medicine and Public Health, Sagami Railway Co. Ltd. Yokohama, Japan
- School of Medicine, Keio University Tokyo Department of Public Health, Sagami Railway Co. Ltd. Yokohama, Japan
- School of Medicine, Juntendo University Tokyo Medical Clinic Yokohama, Japan
- Address correspondence and reprint requests to Yutaka Sakurai, MD, Department of Public Health, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359, Japan.
Abstract
OBJECTIVE To investigate the independent effect of weight change in young adulthood on the risk of prevalent NIDDM among middle-aged Japanese men.
RESEARCH DESIGN AND METHODS A case-control study was carried out in 895 male employees aged ≥ 30 years of a railway company located in the vicinity of Tokyo. Adjusted odds ratios (ORs) were calculated for prevalent diabetes in each category of weight change (obtained from subjects' medical records) in young adulthood and adulthood. Adjustment for current age, initial BMI, and weight change in each age stratum was performed by the Mantel-Haenszel method or multiple logistic regression analysis.
RESULTS Weight change between 20 years of age and the age at maximum weight was not associated with the risk of NIDDM. Weight gain between 20 and 25 years of age was significantly and positively associated with the risk of NIDDM (OR 3.87 for gains ≥ 10.0 kg, 2.53 for gains of 5.0–9.9%, and 3.73 for gains ≥ 10.0%). On the other hand, moderate weight gain after 30 years of age was significantly inversely associated with NIDDM (OR 0.44 for gains of 5.0–9.9 kg, 0.15 for gains of 10.0–19.9%, and 0.38 for gains of 20.0–29.9%).
CONCLUSIONS Extreme weight gain between 20 and 25 years of age is a significant predictor of NIDDM, independent of current age, BMI at 20 years of age, and weight change within other age strata.
- Received August 28, 1996.
- Accepted January 29, 1997.
- Copyright © 1997 by the American Diabetes Association
