Stiffness Indexes β of the Common Carotid and Femoral Arteries Are Associated With Insulin Resistance in NIDDM
- Masanori Emoto, MD,
- Yoshiki Nishizawa, MD,
- Takahiko Kawagishi, MD,
- Kiyoshi Maekawa, MD,
- Yoshikazu Hiura, MD,
- Hiroyuki Kanda, MD,
- Kyoko Izumotani, MD,
- Tetsuo Shoji, MD,
- Eiji Ishimura, MD,
- Masaaki Inaba, MD,
- Yasuhisa Okuno, MD and
- Hirotoshi Morii, MD
- Second Department of Internal Medicine, Osaka City University Medical School Osaka, Japan
- Osaka Municipal Health Promotion Center Osaka, Japan
- Address correspondence and reprint requests to Masanori Emoto, MD, Second Department of Internal Medicine, Osaka City University Medical School, Asahi-machi 1-5-7, Abeno-ku, Osaka, Japan, 545-8585.
Abstract
OBJECTIVE To investigate the association between arterial wall stiffness indexes β of the common carotid artery (CCA) and the femoral artery (FA) and insulin resistance in NIDDM subjects in a cross-sectional study.
RESEARCH DESIGN AND METHODS We evaluated the arterial stiffness indexes β of CCA and FA using an ultrasonic phase-locked echo-tracking system in 60 NIDDM subjects attending the diabetes center in Osaka City University Hospital, compared with 120 ageand sex-matched control subjects. Insulin sensitivity indexes were evaluated using a euglycemic-hyperinsulinemic clamp.
RESULTS Stiffness indexes β of both CCA and FA were significantly higher in NIDDM subjects than in control subjects (CCA 18.1 ± 0.9 vs. 11.7 ± 0.3, respectively, P < 0.001; FA 35.7 ± 2.3 vs. 23.7 ± 0.8, respectively, P < 0.001). The mean insulin sensitivity index in NIDDM subjects was 4.69 ± 0.29 mg · kg−1 · min−1 · mU−1 · 1. The stiffness indexes β of both CCA and FA were inversely correlated with insulin sensitivity indexes (CCA r = −0.393, P = 0.002; FA r = −0.329, P = 0.010), as well as with age, duration of diabetes, and mean blood pressure. In stepwise multiple regression analyses, insulin sensitivity index and duration of diabetes were identified as significant independent variables for stiffness indexes 3 in both CCA and FA (CCA R2 = 0.249, P = 0.0003; FA R2 = 0.336, P < 0.0001).
CONCLUSIONS Arterial stiffness indexes β of CCA and FA were associated with insulin resistance in NIDDM subjects.
- Received November 14, 1997.
- Revision received March 16, 1998.
- Accepted March 16, 1998.
- Copyright © 1998 by the American Diabetes Association
