Idiopathic Type 1 Diabetes?
- Peter H. Bennett, MB, FRCP, FFCM ,
- William C. Knowler, MD, DR PH and
- Jonathan Krakoff, MD
- Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona
The study by Piñero-Piloña et al. entitled “Idiopathic Type 1 Diabetes in Dallas, Texas: A 5-Year Experience” (1) reports on the features of 80 patients who present with diabetic ketoacidosis, the absence of islet cell antibodies, insulin autoantibodies, and GAD antibodies, or HLA antigens associated with type 1 diabetes. The authors then describe the phenotypic characteristics of 54 patients who had follow-up data. When the study began, the patients had a mean age of 34.8 years and a mean BMI of 31.6 kg/m2 and had lost 12.8 kg body wt. All of the subjects reported type 2 diabetes in first-degree relatives, and …
