Association Among Hyperinsulinemia, Family History of Diabetes, and Diminutive Stature in Normoglycemic Premenopausal Women
- F.J. Guerrero-Igea, MD1,
- J.A. Lepe-Jimenez, PHD2,
- A. Garrido-Serrano, MD1 and
- S. Palomo-Gil, MD1
- 1Service of Internal Medicine and
- 2Laboratory Analyses Service, Riotinto Hospital, Minas de Riotinto, Huelva, Spain
Several cross-sectional studies have detected an association between glucose intolerance (1,2) and type 2 diabetes (3–6) with diminutiveness particularly in women. Recently, a longitudinal study confirmed these data (7) but without explanations for the relationship.
Insulin is a hormone that participates actively in protein anabolism (8) during the growth phase, and insulin resistance (of genetic [9,10] or environmental [11] etiology) could be accompanied by a decrease in skeletal development resulting in a diminution of the final height attained. Hence, we tested the hypothesis that hyperinsulinemia or family history of type 2 diabetes is related to decreased stature.
Women attending the …
