Left Ventricular Hypertrophy and Diastolic Dysfunction in Mitochondrial Diabetes
- Yukihiko Momiyama, MD1,
- Yoshihiko Suzuki, MD2,
- Fumitaka Ohsuzu, MD1,
- Yoshihito Atsumi, MD2,
- Kempei Matsuoka, MD2 and
- Mitsuru Kimura, MD2
- 1First Department of Internal Medicine, National Defense Medical College, Saitama
- 2Division of Internal Medicine, Tokyo Saiseikai Central Hospital, Tokyo, Japan
Approximately 1% of diabetes is associated with a mitochondrial tRNA mutation at position 3,243, which was found in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). Left ventricular hypertrophy (LVH) is often reported in MELAS (1).
We studied 12 type 2 diabetic patients with the mutation (DM-Mt3243). They were suspected of the mutation for maternally inherited diabetes or hearing impairment. The mutation was shown in the blood by a molecular test using ApaI. Echocardiography was performed in all of the DM-Mt3243 patients and compared with 184 ordinary type 2 diabetic patients. Between the two groups, age, sex, and diabetes duration were not different. Family history of diabetes in mothers was found in nine DM-Mt3243 patients (75%) and in 48 ordinary …
