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Introduction to Commentaries on the Use of Placebo-Controlled Trials of New Therapies in the Treatment of Type 2 Diabetes

  1. Charles M. Clark, Jr., MD
  1. Regenstrief Institute, Indiana University Medical Center, Indianapolis, Indiana

    As the editor in chief of Diabetes Care, I was stimulated by the thoughtful letter of David S.H. Bell (1) questioning the value and ethics of placebo-controlled trials in the development of new therapeutic agents for the treatment of hyperglycemia in type 2 diabetes, and I decided to look into this issue more in depth. I asked three people to give their perspectives on this issue. The first response, …

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