Association of the Ala54-thr Polymorphism in the Intestinal Fatty Acid–Binding Protein With 2-h Postchallenge Insulin Levels in the Framingham Offspring Study
- Jennifer R. Galluzzi, PHD1,
- L. Adrienne Cupples, PHD2,
- James B. Meigs, MD3,
- Peter W.F. Wilson, MD4,
- Ernst J. Schaefer, MD1 and
- Jose M. Ordovas, PHD1
- 1Lipid Metabolism Laboratory, Jean Mayer–USDA Human Nutrition Research Center on Aging, Tufts University, Boston
- 2Department of Epidemiology and Biostatistics, Boston University School of Public Health, Boston
- 3Department of General Internal Medicine, Massachusetts General Hospital, Boston
- 4The Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts
Abstract
OBJECTIVE—To investigate the association of variants of the intestinal fatty acid–binding protein gene (FABP2) with fasting and postchallenge glucose and insulin levels, HbA1c, and prevalence of type 2 diabetes in a separate sample of men and women.
RESEARCH DESIGN AND METHODS—Subjects were participants in the Framingham Offspring Study, a long-term community-based prospective observational study of risk factors for cardiovascular disease. The study sample consisted of 762 men and 922 women.
RESULTS—In women, carriers of the thr54 allele had significantly higher 2-h postchallenge insulin levels than noncarriers (104.4 ± 73.0 vs. 93.4 ± 61.5 μU/ml; P = 0.0139). This relationship remained significant after adjustment for familial relationship, age, BMI, triglycerides, APOE genotype, smoking, alcohol intake, the use of β-blockers, menopausal status, and estrogen therapy. No such significant association was observed in men. In both men and women, there were no statistical associations between the FABP2 polymorphism and BMI, fasting glucose, fasting insulin, 2-h postchallenge glucose levels, HbA1c, and prevalence of type 2 diabetes.
CONCLUSIONS—These results suggest that the FABP2 thr54 allele may have a minor contribution to the insulin resistance syndrome in a white general population.
- ANOVA, analysis of variance
- CHD, coronary heart disease
- FABP2, fatty acid–binding protein gene
- FOS, Framingham Offspring Study
- IFABP, intestinal fatty acid–binding protein
- LCFA, long-chain fatty acid
- TG, triglyceride
Footnotes
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Address correspondence and reprint requests to Jennifer R. Galluzzi, PhD, Lipid Metabolism Laboratory, J.M.-USDA HNRCA, Tufts University, 711 Washington St., Boston, MA 02111. E-mail: jgalluzzi{at}hnrc.tufts.edu.
Received for publication 17 October 2000 and accepted in revised form 13 March 2001.
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