Absence of Association of Type 2 Diabetes With CAPN10 and PC-1 Polymorphisms in Oji-Cree
- Robert A. Hegele, MD1,
- Stewart B. Harris, MD2,
- Bernard Zinman, MD3,
- Anthony J.G. Hanley, PHD3 and
- Henian Cao, MD1
- 1John P. Robarts Research Institute
- 2Centre for Studies in Family Medicine, University of Western Ontario, London
- 3Samuel Lunenfeld Research Institute and Department of Medicine, Mount Sinai Hospital, University of Toronto, Ontario, Canada. E-mail: robert.hegele@rri.on.ca.
In the Oji-Cree of Northern Ontario, we previously demonstrated that the private HNF1A S319 allele was strongly associated with type 2 diabetes (1), and that the PPARG Q12 allele was associated with both the earlier onset and presence of type 2 diabetes (2). However, HNF1A S319 and PPARG Q12 were present in only ∼60% of Oji-Cree subjects with type 2 diabetes, suggesting that other genetic determinants exist in this population. Recent reports have implicated CAPN10 (3), specifically the UCSNP-43 G allele (also called g.4852G) (4), and PC-1, specifically the Q121 allele (5,6), as possible genetic determinants for type 2 diabetes. We thus evaluated the association of these alleles with type 2 diabetes in the Oji-Cree. …
