Acute Charcot’s Arthropathy Despite 11 Years of Normoglycemia After Successful Kidney and Pancreas Transplantation
- Rossana Caldara, MD1,
- Crispino Grispigni, MD2,
- Ennio La Rocca, MD1,
- Paola Maffi, MD1,
- Elena Orsenigo, MD3,
- Carlo Socci, MD3,
- Gianfranco Fraschini, MD2,
- Valerio Di Carlo, MD3,
- Guido Pozza, MD1 and
- Antonio Secchi, MD1
- 1Departments of Internal Medicine
- 2Orthopedics, and
- 3General Surgery, San Raffaele Scientific Institute, University of Milan, Milan, Italy
Charcot’s arthropathy is one of the most debilitating orthopedic sequelae of diabetes. Regarding its pathogenesis, the current theory suggests a role of diabetic peripheral and autonomic neuropathy (1).
Kidney-pancreas transplantation is an accepted therapeutic approach in uremic type 1 diabetic patients, providing normalization of glycometabolic control and improvement of secondary diabetic complications, including neuropathy (2,3,4).
We report a case of a diabetic uremic patient who developed acute Charcot’s arthropathy despite 11 years of tight metabolic control after successful kidney and pancreas transplantation. A 41-year-old type 1 diabetic uremic male patient underwent kidney and pancreas transplantation. His immunosuppression …
