Subcutaneous Continuous Glucose Monitoring
Feasibility of a new microdialysis-based glucose sensor system
- Karsten Jungheim, MD1,
- Klaas-Jan Wientjes, MD2,
- Lutz Heinemann, PHD3,
- Volker Lodwig, PHD4,
- Theodor Koschinsky, MD, PHD1,
- Adelbert J. Schoonen, PHD2 and
- for the glucose monitoring study group
- 1German Diabetes Research Institute at the Heinrich-Heine University of Duesseldorf, Duesseldorf, Germany
- 2Department of Pharmaceutical Technology and Biopharmacy, University Center of Pharmacy, University of Groningen, Groningen, the Netherlands
- 3Profil Institute for Metabolic Research, Neuss, Germany
- 4Roche Diagnostics, Mannheim, Germany
Devices for continuous glucose monitoring (1,2) should display the data in real time rather than retrospectively. This is possible by means of the microdialysis technique (3). Therefore, we examined the feasibility of continuous glucose monitoring with functional models of a new microdialysis-based subcutaneous continuous glucose monitoring (SCGM) system (Roche Diagnostics, Mannheim, Germany) for up to 72 h. This system was calibrated by a one-point calibration shortly after the beginning of the recording period.
The SCGM system consists of a microdialysis catheter and a portable extracorporal electrochemical glucose sensor. It displays a new glucose value every minute. The system was tested in 23 ambulatory inpatients with insulin-treated type 1 and type 2 diabetes. For comparison, up to 75 capillary blood glucose samples were taken in each patient. …
