“Diabetic Mastopathy,” or Sclerosing Lymphocytic Lobulitis, Is Strongly Associated With Type 1 Diabetes

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Figure 1—
Figure 1—

Histopathologic appearance of sclerosing lymphocytic lobulitis. A: Low-power magnification demonstrates marked lobulitis, with expansion of the collagenous stroma with keloidal features. Note the sharp circumscription of the lymphoid infiltrate, which distinguishes this from chronic nonspecific mastitis (hematoxylin and eosin staining, ×50 magnification). B: This dense lymphoid infiltrate around the lobular unit is atrophic (hematoxylin and eosin staining, ×100 magnification). C: A perivascular infiltrate of mature lymphocytes was seen in all specimens (hematoxylin and eosin staining, ×200 magnification). D: Prominent myofibroblasts, characterized by large, ovoid nuclei and abundant cytoplasm, are dispersed in the keloid-like stroma. These myofibroblasts have a characteristic epithelioid appearance (hematoxylin and eosin staining, ×200 magnification).

This Article

  1. Diabetes Care vol. 25 no. 1 121-126