Tissue Polypeptide–Specific Antigen Serum Concentrations in Children, Adolescents, and Young Adults With Type 1 Diabetes
- Ariadne Malamitsi-Puchner, MD1,
- Adriani Vazeou-Gerasimidi, MD2,
- Angeliki Sarandakou, MSC1,
- John Tziotis, MD1,
- Panagioula Trikka, MD1 and
- Christos S. Bartsocas, MD2
- 1Second Department of Obstetrics and Gynecology, University of Athens, Athens, Greece
- 2Diabetes Center, Department of Pediatrics, Faculty of Nursing, University of Athens, Athens, Greece
Tissue polypeptide–specific antigen (TPS) is a marker of proliferation activity (1,2,3). Because diabetes is characterized by proliferative lesions in various organs, we hypothesized that serum TPS concentrations might be elevated in young patients with type 1 diabetes. Thus, for the first time, serum TPS concentrations in young patients with type 1 diabetes were determined and compared with those of age-matched healthy control subjects. Furthermore, their relation to age, sex, BMI, Tanner stage, insulin requirements, existence of complications, and duration and metabolic control of the disease, as expressed by HbA1c, were investigated. This study was approved by the institutional ethics committee, and informed consent was obtained.
We investigated 97 subjects, 60 with type 1 diabetes …
