Significance of Cord-Blood Leptin in Newborns of Diabetic Mothers

  1. Sylvie Hiéronimus, MD1,
  2. Stéphanie Bastard, MD1,
  3. Jean-Yves Gillet, MD2,
  4. Jean Giudicelli, MD3,
  5. Françoise Brucker-Davis, MD1,
  6. Frédéric Berthier, MD4,
  7. Emmanuel Van Obberghen, PHD5 and
  8. Patrick Fénichel, PHD1
  1. 1Department of Endocrinology, University Hospital of Nice, Nice, France
  2. 2Department of Obstetrics and Gynaecology, University Hospital of Nice, Nice, France
  3. 3Department of Clinical Biochemistry, University Hospital of Nice, Nice, France
  4. 4Department of Biostatistics, University Hospital of Nice, Nice, France
  5. 5INSERM U-145, School of Medicine, Nice, France

    Human fetal adipocyte produces leptin. At birth, cord-blood leptin concentration closely correlates with the amount of newborn fat mass. It is suggested that the sexual dimorphism observed in adults already exists in utero. The higher leptin levels in newborns of diabetic mothers (1) compared with the offspring of nondiabetic mothers could reflect increased adipose tissue. It has also been postulated that hypoxic conditions during pre-eclamspsia affect cord-blood leptin (2) and that fetal insulin stimulates fetal adipocyte leptin production (3).

    We assessed cord-blood levels of leptin and insulin in …

    [Full Text of this Article]
    « Previous | Next Article »Table of Contents

    This Article

    1. doi: 10.2337/diacare.25.10.1886-a Diabetes Care October 2002 vol. 25 no. 10 1886-1887
    1. » Extract
    2. Full Text
    3. Full Text (PDF)

    Current Issue

    1. February 2010, 33 (2)
    1. Current Issue
    1. Alert me to new issues of Diabetes Care