A Subtype of Markedly Abrupt Onset With Absolute Insulin Deficiency in Idiopathic Type 1 Diabetes in Japanese Children
- Tatsuhiko Urakami, MD,
- Makio Nakagawa, MD,
- Shigeo Morimoto, MD,
- Shigeki Kubota, MD,
- Misao Owada, MD and
- Kensuke Harada, MD
- From the Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan
Idiopathic type 1 diabetes, by definition, has no known etiology. Although only a minority of type 1 diabetic patients fall into this category, it is reported that the majority are of African or Asian descent. Individuals with this form of diabetes are considered to present heterogeneous clinical manifestations (1). Imagawa et al. (2) reported a new subtype of type 1 diabetes characterized by fulminant onset, absolute insulin deficiency, and absence of β-cell autoimmunity in Japanese adults. We reported similar cases of idiopathic …
