Erectile Dysfunction and Quality of Life in Type 2 Diabetic Patients

A serious problem too often overlooked

  1. Giorgia De Berardis, MSC (CHEM)1,
  2. Monica Franciosi, MSC (BIOL)1,
  3. Maurizio Belfiglio, MD1,
  4. Barbara Di Nardo, HSDIP1,
  5. Sheldon Greenfield, MD2,
  6. Sherrie H. Kaplan, PHD, MPH2,
  7. Fabio Pellegrini, MS1,
  8. Michele Sacco, MD1,
  9. Gianni Tognoni1,
  10. Miriam Valentini1,
  11. Antonio Nicolucci, MD1 and
  12. for the Quality of Care and Outcomes in Type 2 Diabetes (QuED) Study Group
  1. 1Department of Clinical Pharmacology and Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, S. Maria Imbaro, Italy
  2. 2Department of Tufts University School of Medicine, Boston, Massachusetts

    Abstract

    OBJECTIVE—Within the context of a large, nationwide outcomes research program in type 2 diabetes, we assess the prevalence of self-reported erectile dysfunction and evaluate its impact on quality of life.

    RESEARCH DESIGN AND METHODS—The study involved 1,460 patients enrolled by 114 diabetes outpatient clinics and 112 general practitioners. Patients were asked to complete a questionnaire investigating their ability to achieve and maintain an erection. Various aspects of quality of life were also assessed depressive using the following instruments: SF-36 Health Survey, diabetes health distress, psychological adaptation to diabetes, depressive symptoms (CES-D scale), and quality of sexual life.

    RESULTS—Overall, 34% of the patients reported frequent erectile problems, 24% reported occasional problems, and 42% reported no erectile problems. After adjusting for patient characteristics, erectile dysfunction was associated with higher levels of diabetes-specific health distress and worse psychological adaptation to diabetes, which were, in turn, related to worse metabolic control. Erectile problems were also associated with a dramatic increase in the prevalence of severe depressive symptoms, lower scores in the mental components of the SF-36, and a less satisfactory sexual life. A total of 63% of the patients reported that their physicians had never investigated their sexual problems.

    CONCLUSIONS—Erectile dysfunction is extremely common among type 2 diabetic patients and is associated with poorer quality of life, as measured with generic and diabetes-specific instruments. Despite their relevance, sexual problems are seldom investigated by general practitioners and specialists.

    Footnotes

    • Address correspondence and reprint requests to Antonio Nicolucci, MD, Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Via Nazionale, 66030 S. Maria Imbaro (CH), Italy. E-mail: nicolucc{at}cmns.mnegri.it.

      Received for publication 18 June 2001 and accepted in revised form 16 October 2001.

      A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

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