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Energy Metabolism in Diabetic and Nondiabetic Heart Transplant Recipients

Table 2—

Plasma hormones and substrate concentrations in the postabsorptive state (basal) and during the clamp (clamp)

	D-Tx	Tx	CON
Free insulin (pmol/l)
Basal	96±19*†	41±9	30±5
Clamp	571±38	431±61	360±18
C-peptide (nmol/l)
Basal	1.11±0.1*	1.03±0.17	0.84±0.07
Clamp	0.69±0.07	0.65±0.21	0.42±0.06
Glucagon (ng/l)
Basal	164±30	108±10	87±14
Clamp	191±66	93±12	74±12
Growth hormone (μg/l)
Basal	1.37±0.49	1.38±0.65	0.77±0.13
Clamp	1.74±0.80	0.28±2.52	3.17±1.97
Cortisol (nmol/l)
Basal	284±21	275±78	277±8
Clamp	294±31	202±49	214±6
Epinephrine (pmol/l)
Basal	198±41	186±29	202±26
Clamp	237±40	251±30	221±33
Norepinephrine (units/l)
Basal	1.71±0.42	1.60±0.25	1.42±0.19
Clamp	1.65±0.18	2.06±0.44	1.60±0.11
Lactate (μmol/l)
Basal	791±146	473±44	571±29
Clamp	887±140	626±87	782±41
Pyruvate (μmol/l)
Basal	60±3	64±6	73±6
Clamp	68±6	71±8	76±6
FFAs (mmol/l)
Basal	1.14±0.24*†	0.58±0.07	0.65±0.09
Clamp	0.56±0.29	0.11±0.01	0.11±0.03
Glycerol (μmol/l)
Basal	73.10±8.6*†	40.60±6.30	31.00±5.30
Clamp	31.40±13.00	6.20±2.5*	12.60±0.14
β-OHB (μmol/l)
Basal	209±27	227±116	126±17
Clamp	14±3	12±6	17±5
Alanine (μmol/l)
Basal	227±25	228±44	229±22
Clamp	255±12	231±57	220±15

Data are means ±SEM.
*
↵* P < 0.05 vs. CON;
†
↵† P < 0.05 vs. Tx.

This Article

Diabetes Care March 2002 vol. 25 no. 3 530-536

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February 2012, 35 (2)

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