Difference in the Relation Between Urinary Albumin Excretion and Carotid Intima-Media Thickness in Nondiabetic and Type 2 Diabetic Subjects
- Gilles F.H. Diercks, MD1,
- Erik S.G. Stroes, MD, PHD2,
- Ad J. van Boven, MD, PHD3,
- Arie M. van Roon, PHD4,
- Hans L. Hillege, MD1,
- Paul E. de Jong, MD, PHD5,
- Andries J. Smit, MD, PHD4,
- Rijk O.B. Gans, MD, PHD4,
- Harry J.G.M. Crijns, MD, PHD3,
- Ton J. Rabelink, MD, PHD6 and
- Wiek H. van Gilst, PHD13
- 1Department of Clinical Pharmacology, University of Groningen, Groningen, the Netherlands
- 2Department of Vascular Medicine, Utrecht Medical Center, Utrecht, the Netherlands
- 3Department of Cardiology, Thoraxcenter, Academic Hospital, Groningen, the Netherlands
- 4Department of Internal Medicine, Academic Hospital, Groningen, the Netherlands
- 5Department of Nephrology, Academic Hospital, Groningen, the Netherlands
- 6Department of Internal Medicine, Utrecht Medical Center, Utrecht, the Netherlands
Microalbuminuria is an indicator of an increased cardiovascular risk in diabetic and nondiabetic populations (1,2). Predominantly based on studies in type 2 diabetic populations, it has been suggested that microalbuminuria is an early indicator of atherosclerosis (3). Whether, in nondiabetic subjects, microalbuminuria is an independent indicator of subclinical atherosclerosis or merely a reflection of the increased prevalence of cardiovascular risk factors remains a matter of debate (4). Therefore, in the present study, we investigated the relation between urinary albumin …
