Increase in Serum Uric Acid Is Selectively Associated With Stroke in Type 2 Diabetes
- Giuseppe Seghieri, MD1,
- Daniela Moruzzo, MD2,
- Stefano Fascetti, MD2,
- Clio Bambini, MD2,
- Roberto Anichini, MD3,
- Alessandra De Bellis, MD3,
- Lorenzo Alviggi, MD3 and
- Flavia Franconi, MD4
- 1Department of Internal Medicine, Spedali Riuniti, Pistoia, Italy
- 2Department of Internal Medicine, Ospedale Civile, Viareggio, Italy
- 3Diabetes Unit, Spedali Riuniti, Pistoia, Italy
- 4Department of Pharmacology, University of Sas-sari, Sassari, Italy
Hyperuricemia has previously been described as a strong predictor of well-defined cerebrovascular complications (stroke) in a Finnish cohort of patients with type 2 diabetes (1). To evaluate whether serum uric concentration would be selectively associated with presence of stroke as compared with transient ischemic attack (TIA) in a group of hospitalized diabetic patients, we studied 835 patients (220 affected with type 2 diabetes and 615 nondiabetic subjects), who were consecutively admitted to and subsequently discharged from our hospital for TIA (n = 386) or stroke (n = 449) during the period 1 January 1998 to 31 December 1999. Stroke was classified by means of computerized tomography as ischemic (thromboembolic) in 363 cases (81%) and hemorrhagic in …
