Is HbA1c Influenced More Strongly by Preprandial or Postprandial Glycemia in Type 1 Diabetes?
- Natalia Hillman, MD1,
- Lucrecia Herranz, MD1,
- Cristina Grande, SCD2,
- Africa Villaroel, MB1 and
- Luis F. Pallardo, MD1
- 1Department of Endocrinology and Nutrition, University Hospital La Paz, Madrid, Spain
- 2Department of Biochemistry, University Hospital La Paz, Madrid, Spain
The relative contribution of preprandial and postprandial glycemia to HbA1c has been the subject of increased interest in recent years; however, according to the American Diabetes Association, there are insufficient data to determine this accurately (1).
The objective of our study was to evaluate the accuracy of preprandial and postprandial glycemia in predicting overall glycemic control as estimated by HbA1c in type 1 diabetes.
We analyzed 112 consecutive home blood glucose records from type 1 diabetic patients who were on an intensive diabetes therapy program and who had had diabetes for >5 years. Each home blood glucose record included the blood glucose values performed before and 2 h after breakfast, lunch, and dinner during a period of 6 weeks (mean number of glucose measures performed: 237). HbA1c was measured at the end of each record period by …
