Risk Factors for Microalbuminuria and Macroalbuminuria in Type 2 Diabetic Patients
A 9-year follow-up study
- Marcia Murussi, MD,
- Pierangelo Baglio, MD,
- Jorge L. Gross, MD and
- Sandra P. Silveiro, MD
- Endocrine Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Rio Grande Sul, Brazil
Several risk factors have been related to the development of diabetic nephropathy (DN) in type 2 diabetic patients, such as hyperglycemia, arterial hypertension, dyslipidemia, and smoking (1–5). Higher urinary albumin excretion rate (UAER) levels, even within the normal range, have been suggested to predict the development of DN in type 2 diabetic patients (1,2). Glomerular hyperfiltration has been investigated as a putative risk factor with conflicting results (6,7).
The aim of this study was to analyze risk factors for micro- and macroalbuminuria in a cohort of 52 normoalbuminuric type 2 diabetic patients (UAER <20 μg/min, 30 men, aged 53 ± 6 years, diabetes duration 6 years). Baseline clinical and renal evaluation (glomerular filtration rate [GFR] and UAER measurements) was performed from January 1988 through December 1989 (8). Patients were reevaluated between January 1998 and March 2000; they were followed-up for …
