Association Between Vitamin D Receptor Genotype and Age of Onset in Juvenile Japanese Patients With Type 1 Diabetes
- Ichiro Yokota, MD1,
- Shigeko Satomura, MD1,
- Seiko Kitamura, MD1,
- Yumiko Taki, MD1,
- Etsuo Naito, MD1,
- Michinori Ito, MD1,
- Kahoru Nisisho, MD2 and
- Yasuhiro Kuroda, MD1
- 1Department of Pediatrics, Tokushima University School of Medicine, Tokushima, Japan
- 2Department of Pediatrics, National Kagawa Children’s Hospital, Zentsuji, Japan
1,25-dihydroxyvitamin D3[1,25(OH)2D3] not only regulates calcium metabolism but also modulates the immune system. Some reports have suggested that 1,25(OH)2D3 helps to prevent the development of type 1 diabetes. The association between the vitamin D receptor (VDR) genotype and susceptibility to type 1 diabetes has been examined, but a definitive conclusion has not yet been reached (1,2). We examined the VDR genotype in juvenile Japanese patients with type 1 diabetes.
A total of 108 diabetic patients (41 boys and 67 girls, age of onset 0.4–18 years with a …
