Effect of Losartan on Plasma C-Reactive Protein in Type 2 Diabetic Patients With Microabluminuria
- Kathryn Tan, MD1,
- Wing-Sun Chow, MMBS1,
- Ying Wong, MBBS1,
- Sammy Shiu, BSC1 and
- Sidney Tam, MBBS2
- 1Department of Medicine, University of Hong Kong, Hong Kong, Peoples Republic of China
- 2Clinical Biochemistry Unit, Queen Mary Hospital, Hong Kong, People’s Republic of China
Recent data suggest that the renin-angiotensin system may participate in inflammatory responses and that angiotensin II is a proinflammatory mediator in renal damage (1). An association between C-reactive protein (CRP), a sensitive marker of inflammation, and urinary albumin excretion in the microalbuminuric range has been reported in nondiabetic as well as type 2 diabetic subjects in the Insulin Resistance Atherosclerosis Study (2). Angiotensin II type 1 (AT1) receptor antagonists have been shown to have a renal protective effect and to reduce proteinuria in type 2 diabetic patients with either microalbuminuria or overt nephropathy (3,4,5); therefore, we investigated whether the beneficial effects …
