Elevated Serum Concentration of Adipose-Derived Factor, Adiponectin, in Patients With Type 1 Diabetes
- Akihisa Imagawa, MD, PHD,
- Tohru Funahashi, MD, PHD,
- Tadashi Nakamura, MD, PHD,
- Makoto Moriwaki, MD, PHD,
- Sachiyo Tanaka,
- Hitoshi Nishizawa, MD, PHD,
- Kouichi Sayama, MD,
- Sae Uno, MD,
- Hiromi Iwahashi, MD, PHD,
- Kazuya Yamagata, MD, PHD,
- Jun-ichiro Miyagawa, MD, PHD and
- Yuji Matsuzawa, MD, PHD
- From the Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University
Adiponectin, also referred to as Acrp30, AdipoQ, and GBP28, is a plasma protein exclusively produced by adipose tissue and a possible insulin-sensitizing agent (1–6). Serum adiponectin levels are negatively correlated to BMI in healthy individuals and decreased in type 2 diabetic patients (1–6). However, serum adiponectin levels in type 1 diabetes have not been elucidated.
We examined the serum adiponectin concentrations in 46 type 1 diabetic patients (21 males and 25 females) and compared them with those of BMI-matched healthy control subjects (17 males and 19 females). Mean age was 33 ± 3 and 33 ± 4 years, BMI was 19.8 ± 0.5 and 19.9 ± 0.6 kg/m2, HbA1c level was 9.7± 0.7 and 10.4 ± 0.6%, duration of diabetes was 3.2 ± 0.9 and 3.4 ± 1.3 years, and urinary C-peptide excretion was 18.4 ± 4.3 and 18.0 ± 2.4 μg/day in male and …
