Diabetes and Idiopathic Cardiomyopathy
A nationwide case-control study
- Alain G. Bertoni, MD, MPH1,
- Arthur Tsai, MD2,
- Edward K. Kasper, MD2 and
- Frederick L. Brancati, MD, MHS23
- 1Departments of Public Health Sciences and Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina
- 2Department of Medicine, the Johns Hopkins University School of Medicine, Baltimore, Maryland
- 3Department of Epidemiology, the Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland
- Address correspondence and reprint requests to Dr. Alain Bertoni, Wake Forest University Baptist Medical Center/Public Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157. E-mail: abertoni{at}wfubmc.edu
Abstract
OBJECTIVE—Controversy exists regarding the relation between diabetes and nonischemic idiopathic cardiomyopathy (ICM), and only limited data on the incidence of ICM in adults with diabetes are available. Therefore, we used the 1995 Nationwide Inpatient Sample (NIS) to determine discharge rates and test the hypothesis that diabetes is independently associated with ICM.
RESEARCH DESIGN AND METHODS—The 1995 NIS includes demographic and diagnostic data on all discharges from >900 representative hospitals in 19 states. ICD-9 codes were used to identify ICM, defined as discharges with a diagnosis of primary cardiomyopathy but without established risk factors for cardiomyopathy. Control subjects were selected by stratified random sampling by age to yield 10 per ICM case. The analyzed covariates included age, race, median income, diabetes, and hypertension. Multivariate logistic regression was used to conduct case-control analyses.
RESULTS—Using sampling weights, we estimated that in 1995, the rate of hospital discharge for ICM among individuals diagnosed with diabetes was 7.6 per 1,000. The prevalence of diabetes was substantially higher in the 44,837 ICM vs. 450,254 control subjects (26.6 vs. 17.2%), corresponding to a relative odds (RO) of 1.75 (95% CI 1.71–1.79). After adjusting for age, sex, race, hypertension, and median income using multiple logistic regression, diabetes remained significantly associated with ICM (RO 1.58, 95% CI 1.55–1.62).
CONCLUSIONS—We concluded that diabetes is independently associated with ICM in the general U.S. population.
- CDC, Centers for Disease Control and Prevention
- CHF, congestive heart failure
- ICM, idiopathic cardiomyopathy
- NIS, Nationwide Inpatient Sample
Footnotes
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A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.
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See accompanying editorial, p. 2949.
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- Accepted May 4, 2003.
- Received January 30, 2003.
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