Prospective Study of the Association Between the Proline to Alanine Codon 12 Polymorphism in the PPARγ Gene and Type 2 Diabetes

  1. Asli Memisoglu, SCD1,
  2. Frank B. Hu, MD2,
  3. Susan E. Hankinson, SCD13,
  4. Simin Liu, MD4,
  5. James B. Meigs, MD5,
  6. David M. Altshuler, MD6,
  7. David J. Hunter, MD137 and
  8. JoAnn E. Manson, MD134
  1. 1Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
  2. 2Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
  3. 3Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, Massachusetts
  4. 4Division of Preventive Medicine, Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, Massachusetts
  5. 5General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
  6. 6Department of Genetics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
  7. 7Harvard School of Public Health, Center for Cancer Prevention, Boston, Massachusetts
  1. Address correspondence and reprint requests to Asli Memisoglu, SCD, Harvard School of Public Health, 677 Huntington Ave., Bldg. II Rm. 109, Boston, MA 02115. E-mail: amemisog{at}hsph.harvard.edu

Abstract

OBJECTIVE—To determine whether the Pro12Ala polymorphism in the PPARγ gene was associated with risk of type 2 diabetes in the Nurses’ Health Study.

RESEARCH DESIGN AND METHODS—The study was a nested case-control study of 387 incident cases of type 2 diabetes and 771 matching control subjects nested within the Nurses’ Health Study, a prospective cohort study. Association between PPARγ genotype and incident type 2 diabetes was estimated using logistic regression.

RESULTS—Carriers of the PPARγ variant 12Ala allele had reduced risk of type 2 diabetes compared with noncarriers. Unadjusted and adjusted odds ratios of type 2 diabetes were 0.74 (95% CI 0.55–1.00) and 0.72 (0.52–0.99), respectively.

CONCLUSIONS—The results of this study provide further support for an inverse association between the PPARγ variant 12Ala allele and risk of type 2 diabetes.

Footnotes

  • A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

    • Accepted June 25, 2003.
    • Received March 26, 2003.
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  1. doi: 10.2337/diacare.26.10.2915 Diabetes Care October 2003 vol. 26 no. 10 2915-2917
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