Predictive Value of Autoantibodies to IA-2 for Insulin Requirements in Japanese Subjects With Type 1 Diabetes
- Tsuguhito Ota, MD, PHD1,
- Toshinari Takamura, MD, PHD1,
- Yukihiro Bando, MD, PHD2,
- Rika Usuda, MD, PHD3 and
- Yukihiro Nagai, MD, PHD1
- 1Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
- 2Department of Internal Medicine, Fukui-ken Saiseikai Hospital, Fukui, Japan
- 3Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyama, Japan
- Address correspondence to Toshinari Takamura, MD, PhD, Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, Japan. E-mail: tt{at}medf.m.kanazawa-u.ac.jp
GAD autoantibodies (GADAs) are frequently detected before the onset of diabetes and indicate the development of insulin dependency (1). Phosphatase-like protein IA-2 antibodies (IA-2As) in combination with GADA have been shown to improve the positive predictive value for type 1 diabetes (2). However, the presence of IA-2A and its clinical usefulness in Japanese type 1 diabetic patients have not been fully determined. Here we report the significance of serum antibodies to IA-2A and GADA to predict the insulin requirement in Japanese patients with type 1 diabetes.
We studied 101 Japanese patients with type …
