Plasma Adiponectin Is an Independent Predictor of Type 2 Diabetes in Asian Indians
- Chamukuttan Snehalatha, MSC, DSC1,
- Bheekamchand Mukesh, MBBS1,
- Mary Simon, BSC1,
- Vijay Viswanathan, MD, PHD1,
- Steven M. Haffner, MD2 and
- Ambady Ramachandran, MD, PHD, FRCP1
- 1Diabetes Research Centre, M.V. Hospital for Diabetes, WHO Collaborating Centre for Research, Education & Training in Diabetes, Royapuram, Chennai, India
- 2Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center of San Antonio, San Antonio, Texas
- Address correspondence and reprint requests to Prof. A. Ramachandran, Director, Diabetes Research Centre, M.V. Hospital for Diabetes & WHO Collaborating Centre for Research, Education & Training in Diabetes, 4 Main Rd., Royapuram, Chennai 600 013, India. E-mail: ramachandran{at}vsnl.com
Abstract
OBJECTIVE—Adiponectin, secreted by fat cells, has regulatory functions on energy metabolism. Its low levels are predictive of future development of diabetes. Because no studies on the regulatory role of adiponectin in glucose homeostasis in Asian Indians exist, this analysis was performed to determine the prospective association of adiponectin and diabetes in subjects with impaired glucose tolerance (IGT).
RESEARCH DESIGN AND METHODS—Baseline values of plasma adiponectin, results of anthropometry, fasting and 2-h plasma glucose levels, HbA1c, results of lipid profile, and insulin resistance were analyzed in 91 subjects with IGT (53 men and 38 women) in a primary prevention study. Reassessment of glucose tolerance was performed during 1-year review. The predictive nature of adiponectin for development of diabetes was assessed using univariate and multiple logistic regression analyses. A control group comprising healthy, normoglycemic individuals was used for comparison.
RESULTS—At follow-up, diabetes had developed in 25 of the 91 study subjects. The mean baseline adiponectin level was lower in the diabetic subjects than in the nondiabetic subjects (11.3 ± 5.5 vs. 16.7 ± 7.6 μg/ml, P = 0.0017). Low adiponectin level was a strong predictor of future development of diabetes, and HbA1c also showed a positive predictive association. Women had higher adiponectin levels (16.4 ± 6.1 μg/ml) than men (13.9 ± 7.6 μg/ml) (P = 0.035).
CONCLUSIONS—In Asian Indians, low plasma adiponectin level was predictive of future development of diabetes.
Footnotes
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A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.
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- Accepted August 26, 2003.
- Received June 5, 2003.
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