Maturity-Onset Diabetes of the Young (MODY) Mutation in Type 2 Diabetes and Latent Autoimmune Diabetes of the Adult

  1. James McKinney, BSC1,
  2. Henian Cao, MD1,
  3. Margaret T. Behme, PHD2,
  4. Jeffrey L. Mahon, MD2 and
  5. Robert A. Hegele, MD1
  1. 1Robarts Research Institute, London, Ontario, Canada
  2. 2Department of Medicine, Epidemiology, and Biostatistics, University of Western Ontario, London, Ontario, Canada
  1. Address correspondence to Robert A. Hegele, 100 Perth Dr., London, Ontario, Canada N6A5K8. E-mail: hegele{at}

Owen et al. (1) reported etiologic heterogeneity among 268 subjects with type 2 diabetes, of whom ∼10% had autoantibodies and ∼1% had mutations in HNF1A (MODY3) encoding hepatic nuclear factor-1α. We hypothesized that maturity-onset diabetes of the young (MODY) gene mutations would also be found in subjects with latent autoimmune diabetes of the adult (LADA) (2). We studied 37 Canadian subjects diagnosed with LADA (of whom 20 were female) and …

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