A Prospective Study of Self-Reported Sleep Duration and Incident Diabetes in Women

  1. Najib T. Ayas, MD12,
  2. David P. White, MD12,
  3. Wael K. Al-Delaimy, MD, PHD3,
  4. JoAnn E. Manson, MD, DRPH2456,
  5. Meir J. Stampfer, MD, DRPH346,
  6. Frank E. Speizer, MD26,
  7. Sanjay Patel, MD12 and
  8. Frank B. Hu, MD, PHD346
  1. 1Division of Sleep Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston
  2. 2Harvard Medical School, Boston
  3. 3Department of Nutrition, Harvard School of Public Health, Boston
  4. 4Department of Epidemiology, Harvard School of Public Health, Boston
  5. 5Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston
  6. 6Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts

    Abstract

    Short-term sleep restriction results in impaired glucose tolerance. To test whether habitually short sleep duration increases the risk of developing diabetes, we studied a cohort of 70,026 women enrolled in the Nurses Health Study, without diabetes at baseline, and who responded to a question about daily sleep duration in 1986. Subjects were followed until 1996 for the diagnosis of diabetes (1,969 cases). Long and short sleep durations were associated with an increased risk of diabetes diagnosis. The relative risks (RRs) for short (slept ≤5 h per day) and long (slept ≥9 h per day) sleepers were 1.57 (95% CI 1.28–1.92) and 1.47 (1.19–1.80), respectively. After adjustment for BMI and a variety of confounders, the RR was not significantly increased for short sleepers (1.18 [0.96–1.44]) but remained modestly increased for long sleepers (1.29 [1.05–1.59]). We then performed a similar analysis using only symptomatic cases (n = 1,187). Adjusted RRs for symptomatic diabetes were modestly elevated in both short (1.34 [1.04–1.72]) and long (1.35 [1.04–1.75]) sleepers. Our data suggest that the association between a reduced self-reported sleep duration and diabetes diagnosis could be due to confounding by BMI, or sleep restriction may mediate its effects on diabetes through weight gain. Sleep restriction may be an independent risk factor for developing symptomatic diabetes.

    Footnotes

    • Address correspondence and reprint requests to Frank B. Hu, MD, PhD, Dept. of Nutrition, Harvard School of Public Health, 665 Huntington Ave., Boston, MA 02115. E-mail: frank.hu{at}channing.harvard.edu.

      Received for publication 16 July 2002 and accepted in revised form 29 October 2002.

      A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

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