Leptin Is Reduced in Lean Subjects With Type 2 Diabetes in Bangladesh
- Mohammed Abu Sayeed, MBBS, DCM, MD, PHD1,
- Abul Kalam Azad Khan, MBBS, FCPS, PHD1,
- Hajera Mahtab, MBCHB, DTM&H, FCPS, FRCP1,
- Khandaker Abdul Ahsan, MBBS1,
- Akhtar Banu, MBBS, MSC, PHD1,
- Parvin Akter Khanam, MSC1 and
- Bo Ahrén, MD, PHD2
- 1Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh
- 2Department of Medicine, Lund University, Lund, Sweden
Although leptin levels are increased in obesity (1), obese subjects with type 2 diabetes display reduced leptin (2–4), which may be due to altered fat distribution (5). This study examined whether leptin levels are also reduced in lean subjects with type 2 diabetes.
Fifty nonobese Bangladeshi women with type 2 diabetes (aged 37.2 ± 1.3 years) were selected randomly from the Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) outpatient department (28 were on diet and exercise, and 22 were on oral hypoglycemic agents; HbA …
