HLA-DR-DQ Haplotype in Rapid-Onset Type 1 Diabetes in Japanese
- Tomoatsu Nakamura, MD,
- Shoichiro Nagasaka, MD,
- Ikuyo Kusaka, MD,
- Toshimitsu Yatagai, MD,
- Jianmei Yang, MD and
- Shun Ishibashi, MD
- From the Division of Endocrinology and Metabolism, Jichi Medical School, Tochigi, Japan
Type 1 diabetes is characterized by the presence of insulitis and autoantibodies, at least in the earlier course of the disease. It is well known that HLA locus confers strong genetic susceptibility to the disease. Imagawa et al. (1) described a unique subtype of type 1 diabetes that shows a rapid and fulminant onset of the disease but lacks evidence of insulitis and autoantibodies. Although the etiology of this unique subtype of type 1 diabetes is unclear at present, Tanaka et al. (2) very recently reported that specific HLA-DQ genotypes may be associated with this subtype of type 1 diabetes. Here, we report clinical characteristics of subjects with type 1 diabetes of a rapid and fulminant onset who were collected from the registration of type 1 diabetes in our institution.
We identified 19 type 1 diabetic subjects showing an acute and abrupt onset of diabetes …
