Increased Oxidative Stress Is Associated With Elevated Plasma Levels of Adrenomedullin in Hypertensive Patients With Type 2 Diabetes
- Akira Katsuki, MD1,
- Yasuhiro Sumida, MD1,
- Hideki Urakawa, MD1,
- Esteban C. Gabazza, MD1,
- Noriko Maruyama, MD1,
- Kohei Morioka, MD1,
- Nagako Kitagawa, MD1,
- Yasuko Hori, MD1,
- Kaname Nakatani, MD2,
- Yutaka Yano, MD1 and
- Yukihiko Adachi, MD1
- 1Third Department of Internal Medicine, Mie University School of Medicine, Mie, Japan
- 2Department of Laboratory Medicine, Mie University School of Medicine, Mie, Japan
Previous studies have demonstrated that oxidative stress is associated not only with hyperglycemia and hypertension but also with the metabolic syndrome and cadiovascular disease (1–3).
Adrenomedullin (AM) is a novel vasorelaxant peptide isolated from human pheochromocytoma (4,5). Oxidative stress enhances AM production from endothelium and vascular smooth muscle cells in vitro (6,7). However, whether oxidative stress is associated with circulating levels of AM in vivo is unknown. In the present study, we evaluated the relationship between the plasma levels of 8-epi-prostaglandinF2α (8-epi-PGF2α; currently regarded as the most reliable marker for the assessment of oxidative stress in humans) (8,9) and AM in normal subjects and hypertensive patients with type 2 diabetes.
This study comprised 17 hypertensive patients with type 2 diabetes (15 men and 2 women, age 47.3 ± 3.0 years [mean ± SE], BMI 23.2 ± 0.8 kg/m2, fasting plasma glucose 8.2 ± 0.5 mmol/l, HbA1c 9.9 ± 0.5%, fasting serum insulin 30.6 ± 3.0 …
