Cytokine Milieu Tends Toward Inflammation in Type 2 Diabetes
- Katherine Esposito, MD,
- Francesco Nappo, MD, PHD,
- Francesco Giugliano,
- Carmen Di Palo,
- Myriam Ciotola,
- Michelangela Barbieri, MD,
- Giuseppe Paolisso, MD and
- Dario Giugliano, MD, PHD
- From the Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
It has been postulated that type 2 diabetes is a manifestation of the inflammatory host response (1). Increased inflammatory activity is believed to play a critical role in development of atherogenesis and to predispose established atherosclerotic plaques to rupture (2). Interleukin (IL)-8 is a potent chemoattractant (chemokine) and induces recruitment of neutrophils and T-cells into the subendothelial space, as well as adhesion of monocytes to endothelium (3). IL-18 is a potent proinflammatory cytokine reported to play a role in plaque destabilization and to predict cardiovascular death in patients with coronary artery disease (4). Adiponectin is an …
