Lipoprotein Abnormalities in Human Genetic CD36 Deficiency Associated With Insulin Resistance and Abnormal Fatty Acid Metabolism
- Takahiro Kuwasako, MD1,
- Ken-ichi Hirano, MD, PHD1,
- Naohiko Sakai, MD, PHD1,
- Masato Ishigami, MD, PHD1,
- Hisatoyo Hiraoka, MD, PHD1,
- Mohamed Janabi Yakub, MD, PHD1,
- Keiko Yamauchi-Takihara, MD, PHD2,
- Shizuya Yamashita, MD, PHD1 and
- Yuji Matsuzawa, MD, PHD1
- 1Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
- 2Department of Molecular Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
CD36 is an 88-kDa membranous protein with multiple relevant function that is widely expressed in human tissues (1). Because we and others (2) found human genetic deficiency of this molecule, we have elucidated the molecular bases and pathophysiology. We have reported that the human deficiency may be associated with insulin resistance (3) and abnormal dynamics of long-chain fatty acid (LCFA) (4). The aim of the present study was to further characterize lipid and lipoprotein metabolism in the human genetic CD36 deficiency, especially focusing on postprandial …
