Differential Levels of γ-Glutamyl Transferase Activity and Apolipoprotein CIII in Men on Either Statin or Fibrate Therapy
- Laurence Mabile, PHD12,
- Jean-Bernard Ruidavets, MD1,
- Josette Fauvel, PHD3,
- Bertrand Perret, MD2 and
- Jean Ferrières, MD, FESC1
- 1Département d’Epidémiologie, Inserm U558, Faculté de Médecine, Toulouse, France
- 2Inserm U563, CHU Toulouse, France
- 3Laboratoire de Biochimie III, CHU Toulouse, France
High triglycerides and low HDL cholesterol are frequently associated with insulin resistance. Statins are potent hypocholesterolemic drugs, while fibrates are better at reducing triglycerides and enhancing HDL. However, little is known of their effects on other parameters potentially associated with insulin resistance, such as γ-glutamyl transferase (GGT) (1) and apolipoprotein CIII (2).
In this cross-sectional study, we have analyzed the biochemical profiles of 500 men from Southwestern France as a function of their hypolipidemic therapy. Comparison between untreated (n = 361) and fibrate …
