IGF Binding Protein-1 and Carotid Intima-Media Thickness in Type 2 Diabetes
Response to Conti et al.
- Eeva S. Leinonen, MD1,
- Pekka J. Leinonen, MD, PHD2 and
- Marja-Riitta Taskinen, MD, PHD1
- 1Department of Internal Medicine, Helsinki University Central Hospital, Helsinki, Finland
- 2Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
We thank Conti et al. (1) for their interest in our recent article (2) and the editor for the opportunity to further discuss the role of the IGF system in atherosclerosis.
We found an inverse relation between IGF binding protein-1 (IGFBP-1) and carotid intima-media thickness (IMT) in type 2 diabetic patients. In the linear regression model for diabetic subjects with cardiovascular disease (CVD), IGFBP-1 was one of the main …
