Prospective Relation of C-Reactive Protein With Type 2 Diabetes
Response to Han et al.
- Marieke B. Snijder, MSC1,
- Jacqueline M. Dekker, PHD1,
- Marjolein Visser, PHD1,
- Coen D.A. Stehouwer, MD, PHD12,
- John S. Yudkin, MD13,
- Lex M. Bouter, PHD1,
- Robert J. Heine, MD, PHD14,
- Giel Nijpels, MD, PHD1 and
- Jacob C. Seidell, PHD15
- 1Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, the Netherlands
- 2Department of Internal Medicine, VU University Medical Center, Amsterdam, the Netherlands
- 3Department of Medicine, Diabetes and Cardiovascular Disease Academic Unit, University College London Medical School, London, U.K
- 4Department of Endocrinology, VU University Medical Center, Amsterdam, the Netherlands
- 5Department of Nutrition and Health, Faculty of Earth and Life Sciences, Vrije Universiteit, Amsterdam, the Netherlands
We read with great interest the article by Han et al., which was recently published in Diabetes Care (1). The authors studied the association between baseline levels of C-reactive protein (CRP) and the 6-year incidence of the metabolic syndrome and type 2 diabetes in Mexican subjects. They found an odds ratio (OR) of 4.1 (95% CI 2.1–8.0) for developing the metabolic syndrome and an OR of 5.4 (2.2–13.4) for incident type 2 diabetes among women in the highest compared with the lowest tertile of CRP. ORs were adjusted for age, smoking, physical activity, and alcohol intake. In men, no such association was found. Additional adjustment for BMI slightly lowered the ORs; adjustment for waist-to-hip …
