Prospective Relation of C-Reactive Protein With Type 2 Diabetes
Response to Snijder et al.
- Naveed Sattar, MD, PHD1,
- Ken Williams, MS2,
- Thang S. Han, MD, PHD3,
- Clicerio Gonzalez-Villalpando, MD4,
- Michael E.J. Lean, MD, FRCP5 and
- Steven M. Haffner, MD, MPH2
- 1University Department of Pathological Biochemistry, Glasgow Royal Infirmary, Glasgow U.K
- 2Department of Medicine #7873, University of Texas Health Science Center at San Antonio, San Antonio, Texas
- 3Addenbrooke’s Hospital, Cambridge University Medical School, Cambridge, U.K
- 4Center de Estudios in Diabetes, Mexico City, Mexico
- 5University Department of Human Nutrition, Glasgow Royal Infirmary, Glasgow, U.K
We thank Snijder et al. (1) for their interest in our article (2) and for sharing their data relating C-reactive protein (CRP) to the risk of diabetes development in the Hoorn Study. We readily agree that it is unclear why inflammation might be more important to the pathogenesis of type 2 diabetes in women compared with men or indeed vice versa. We have reanalyzed our CRP data using the same covariates as Snijder et al. and essentially our results are unchanged—the relation between CRP and diabetes remains strong in women, even after inclusion of waist-to-hip ratio (WHR), but is absent …
