β2-Adrenergic Receptor Polymorphism and Obesity in Type 2 Diabetes
Response to Yoshioka, Yoshida, and Yoshikawa
- Jonathan H. van Tilburg, PHD1,
- Cisca Wijmenga, PHD1 and
- Timon W. van Haeften, MD2
- 1Department of Biomedical Genetics, University Medical Center, Utrecht, the Netherlands
- 2Department of Internal Medicine, University Medical Center, Utrecht, the Netherlands
We recently reported that our group (n = 502) of type 2 diabetic subjects did not reveal statistically significant differences in BMI with respect to the three groups of carriers of β2-adrenergic receptor polymorphisms (1). Meirhaghe et al. (1) report that in men not participating in physical activity, Gln27Gln carriers had a higher BMI than the Glu27 (combined heterozygous and homozygous) carriers (27.2 ± 0.4 vs. 25.2 ± 0.3 kg/m2), while no effect on BMI was found …
