Type 2 Diabetes and Subsequent Incidence of Breast Cancer in the Nurses’ Health Study

  1. Karin B. Michels, SCD123,
  2. Caren G. Solomon, MD2,
  3. Frank B. Hu, MD24,
  4. Bernard A. Rosner, PHD25,
  5. Susan E. Hankinson, SCD23,
  6. Graham A. Colditz, MD23 and
  7. JoAnn E. Manson, MD23
  1. 1Obstetrics and Gynecology Epidemiology Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
  2. 2Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts
  3. 3Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
  4. 4Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
  5. 5Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts

    Abstract

    OBJECTIVE—Hyperinsulinemia may promote mammary carcinogenesis. Insulin resistance has been linked to an increased risk of breast cancer and is also characteristic of type 2 diabetes. We prospectively evaluated the association between type 2 diabetes and invasive breast cancer incidence in the Nurses’ Health Study.

    RESEARCH DESIGN AND METHODS—A total of 116,488 female nurses who were 30–55 years old and free of cancer in 1976 were followed through 1996 for the occurrence of type 2 diabetes and through 1998 for incident invasive breast cancer, verified by medical records and pathology reports.

    RESULTS—During 2.3 million person-years of follow-up, we identified 6,220 women with type 2 diabetes and 5,189 incident cases of invasive breast cancer. Women with type 2 diabetes had a modestly elevated incidence of breast cancer (hazard ratio [HR] = 1.17; 95% CI 1.01–1.35) compared with women without diabetes, independent of age, obesity, family history of breast cancer, history of benign breast disease, reproductive factors, physical activity, and alcohol consumption. This association was apparent among postmenopausal women (1.16; 0.98–1.62) but not premenopausal women (0.83; 0.48–1.42). The association was predominant among women with estrogen receptor-positive breast cancer (1.22; 1.01–1.47).

    CONCLUSIONS—Women with type 2 diabetes may have a slightly increased risk of breast cancer.

    Footnotes

    • Address correspondence and reprint requests to Karin B. Michels, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave., Boston, MA 02115. E-mail: kmichels{at}rics.bwh.harvard.edu.

      Received for publication 7 September 2002 and accepted in revised form 21 February 2003.

      A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

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