No Association Between the MTHFR Gene Polymorphism and Diabetic Retinopathy in Type 2 Diabetic Patients Without Overt Nephropathy
Response to Maeda et al.
- Keiji Yoshioka, MD1,
- Toshihide Yoshida, MD2,
- Yasuto Takakura, MD2,
- Akinori Kogure, MD2,
- Tsunekazu Umekawa, MD2,
- Hitoshi Toda, MD3 and
- Toshikazu Yoshikawa, MD2
- 1Department of Diabetes and Endocrinology, Matsushita Memorial Hospital, Moriguchi, Japan
- 2Department of Endocrinology, Diabetes and Metabolism, Kyoto Prefectual University of Medicine, Kyoto
- 3Sakazaki Clinic, Kyoto, Japan
Maeda et al. (1) have recently demonstrated that the presence of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene in diabetic patients can be a predictive for diabetic retinopathy (DR), especially nonproliferative DR (NPDR). We also genotyped the MTHFR polymorphism (C677T) in 366 type 2 diabetic patients without overt nephropathy, and no such association was found. The subjects had a mean age of 60.0 years, duration of diabetes of 11.7 years, HbA1c of 7.3%, and serum creatinine of 0.71 mg/dl. The patients with urinary …
