Decreased Serum Levels of Adiponectin Are a Risk Factor for the Progression to Type 2 Diabetes in the Japanese Population
The Funagata study
- Makoto Daimon, MD1,
- Toshihide Oizumi, MD1,
- Tamotsu Saitoh, MD1,
- Wataru Kameda, MD1,
- Akihiko Hirata, MD2,
- Hiroshi Yamaguchi, MD1,
- Hiroshi Ohnuma, MD1,
- Masahiko Igarashi, MD2,
- Makoto Tominaga, MD2 and
- Takeo Kato, MD1
- 1Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
- 2Department of Laboratory Medicine, Yamagata University School of Medicine, Yamagata, Japan
- Address correspondence and reprint requests to Makoto Daimon, MD, Third Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan. E-mail: mdaimon{at}med.id.yamagata-u.ac.jp.
Abstract
OBJECTIVE—To examine whether decreased serum levels of adiponectin are an independent risk factor for the progression to type 2 diabetes in a Japanese population.
RESEARCH DESIGN AND METHODS—The serum levels of adiponectin and tumor necrosis factor-α (TNF-α) at baseline (from 1995 to 1997) were evaluated in 1,792 individuals (1,023 women and 769 men, aged 58.5 ± 12.5 years) from a cohort population (n = 3,706) of the Funagata study. Glucose tolerance was evaluated at baseline and also at 5-year follow-up examinations (n = 978, follow-up rate, 54.6%) according to the 1985 World Health Organization criteria. The correlation of clinical traits with serum levels of adiponectin was examined. The association of the traits with the progression to type 2 diabetes at the 5-year follow-up was also examined.
RESULTS—Among the traits examined, the correlation with aging was highest (r = 0.312, P < 0.001). Eighteen subjects with normal glucose tolerance (NGT) developed diabetes, and 709 remained NGT at the 5-year follow-up examinations. The subjects who became diabetic had decreased serum levels of adiponectin (7.29 ± 2.35 vs. 9.13 ± 2.35 10 × log μg/ml, P = 0.009). Multiple logistic regression analysis with age, sex, waist-to-hip ratio, and 2-h plasma glucose as the variables revealed that serum adiponectin level (odds ratio [per 0.1 log μg/ml] 0.766, P = 0.029) was an independent risk factor for the progression to type 2 diabetes. The subjects whose serum levels of adiponectin were in the lowest tertile were 9.320 times (95% CI 1.046–83.1) more likely to develop diabetes than those in the highest tertile (P = 0.046).
CONCLUSIONS—Decreased serum adiponectin level is an independent risk factor for progression to type 2 diabetes.
- ELISA, enzyme-linked immunosorbent assay
- HOMA-IR, homeostasis model assessment of insulin resistance
- IGT, impaired glucose tolerance
- NGT, normal glucose tolerance
- PAI-1, plasminogen-activator inhibitor type 1
- TNF-α, tumor necrosis factor-α
- WHR, waist-to-hip ratio
Footnotes
-
A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.
-
- Accepted April 15, 2003.
- Received December 21, 2002.
- DIABETES CARE
